top of page

B-Cell Receptor: IgM Structure

Writer: Joy BREWERJoy BREWER
Apr 28, 20231 min read

This drawing depicts the Immunoglobulin M isotype (IgM) of a B-cell receptor (BCR). As depicted, Igα/Igβ still contain Immunoreceptor tyrosine-based activation motifs (ITAM). However, studies show that IgM BCRs differ from the soluble pentameric IgM in a number of ways. First, as shown in the drawing, the Igα/Igβ heterodimer sandwich one of the heavy chain transmembrane domains. Additionally, there are 14 glycosylation sites, eight on the heterodimers and 6in the constant region (Fc).


By: Joy Brewer

January 29, 2023


 
 
 

Recent Posts

See All

End-of-term Reflection

There were so many things that interested me in this class and that apply to my area of study. However, what stood out to me most was...

 
 
 

Comments

bottom of page